Computational Simulations of the Early Steps of Protein Aggregation
نویسندگان
چکیده
منابع مشابه
Computational simulations of the early steps of protein aggregation.
There is strong evidence that the oligomers of key proteins, formed during the early steps of aggregation, could be the primary toxic species associated with human neuro-degenerative diseases, such as Alzheimer's and prion diseases. Here, we review recent progress in the development of computational approaches in order to understand the structures, dynamics and free energy surfaces of oligomers...
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ژورنال
عنوان ژورنال: Prion
سال: 2007
ISSN: 1933-6896,1933-690X
DOI: 10.4161/pri.1.1.3969